Two sample MR report
KANSL1-AS1_T Proliferating against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 71 | -0.0629230 | 0.0751784 | 0.4054919 |
| Weighted median | 71 | -0.1013807 | 0.0125240 | 0.0000000 |
| Inverse variance weighted | 71 | -0.0796327 | 0.0092339 | 0.0000000 |
| Simple mode | 71 | -0.1088892 | 0.0270502 | 0.0001421 |
| Weighted mode | 71 | -0.1075470 | 0.0267259 | 0.0001428 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 42.43175 | 69 | 0.9951047 |
| Inverse variance weighted | 42.48191 | 70 | 0.9962000 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0118485 | 0.0529039 | 0.8234475 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0010059 | 0 | TRUE | 0.0026192 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
